Benjamin
Schwartz, PhD

Investigator, Head, Center for Molecular Innovation, The Feinstein Institute for Medical Research

Professor of Molecular Medicine and Medicine, Hofstra Northwell School of Medicine

Phone:

(516) 949-8809

Email:

About the researcher:

Member of Feinstein Institute for Medical Research

Specialty:

Genetics/Molecular Innovation

Bio:

Bio... Read more

Research focus:

Autoimmune and inflammatory diseases

Autoimmune diseases affect an estimated 22 million Americans, and their incidence is rapidly growing. These disorders are conditions in which immunological tolerance is defective and normal tissues are targeted for destruction. Although the precise cause of these diseases remains unclear, both genetic and environmental factors confer disease susceptibility.

Therapeutic and preventative strategies for autoimmune disease have been largely disappointing. Anti-cytokine hterapies (particularly anti-TNF therapeutics in rheumatoid arthritis) are the newest and most exciting form of therapy, but their high cost of production precludes their widespread use . Moreover, in the case of anti-TNF therapy, 40% of patients receving therapy do not respond to treatment for unknown reasons. Thus, autoimmune diseases remain a largely unmet medical need.

Neurodegenerative diseases

Semapimod (formally known as CNI-1493) has undergone phase II clinical trials in Crohn’s disease, and although it lacked statistically meaningful efficacy in these trials, it was demonstrated to be a well-tolerated drug (non-toxic) with largely minimal, self-limiting side effects. The team recently identified CNI-1493 as a potential drug candidate for the treatement of neurodegenrative diseases. Currently, they are focusing thier attention to bring this drug to clinical trials in Alzheimer’s and Parkinson’s diseases.

Research training opportunities for residents and fellows:

  • Transient elastography in hepatitis B
  • Transient elastography in dialysis patients awaiting transplantation
  • Fatty liver disease and diabetes

Education

University of Tübingen, Tübingen, Germany

Degree: PhD
1994
Field of study: Organic chemistry

Jordan University, Amman, Jordan

Degree: MSc
1990
Field of study: Organic chemistry

College of Science and Technology, Jerusalem

Degree: BSc
1986
Field of study: Chemistry

Lab members

Kai Fan Cheng, PhD

Research Scientist
Email: kcheng2@nshs.edu

Bayan Al-Jabari, BS

Research Assistant
Email: balajber@nshs.edu

Mingzhu He, PhD

Research Scientist
Email: aragab@nshs.edu

Kai Fan Cheng, PhD

Research Scientist
Email: kcheng2@nshs.edu

Bayan Al-Jabari, BS

Research Assistant
Email: balajber@nshs.edu

Mingzhu He, PhD

Research Scientist
Email: aragab@nshs.edu

Honors and awards

1990 - 1993

Deutscher Akademischer Austausschdienst (DAAD) Fellow

1998 - 1999

Alexander von Humboldt Award

1997 - 1999

American Heart Association Award

2007 - 2008

Alzheimer Drug Discovery Foundation & Elan

2007 - 2010

American Heart Association Award

Publications

View more publications on PubMed

I'm not going to type all that.

Nor this.

Nor that.

View more publications

<