David Jonathan Langer, MD

David Jonathan Langer, MD

Chief, Neuro-Endovascular Surgery and Interventional Neuroradiology
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Chair, Department of Neurosurgery
Lenox Hill Hospital

Director
Moyamoya Center

Professor of Neurosurgery
Hofstra Northwell School of Medicine

David Langer, MD is the chair of neurosurgery at Lenox Hill Hospital. Internationally recognized as an expert in cerebral revascularization and cerebral aneurysms, his work focuses on diseases of the brain vessels. Dr. Langer's work has been featured in numerous peer-reviewed publications and he has spoken nationally and internationally on vascular disorders such as aneurysms and arteriovenous malformations (AVMs) of the brain. He is one of the few cerebral bypass surgeons in the country.

A third generation physician, Dr. Langer attended the University of Pennsylvania for undergraduate and medical school. He stayed on at Penn and completed his neurosurgical residency under the direction of Eugene S. Flamm, MD. He went on to join Dr. Flamm at a new neurosurgical institute in New York City in 1998. Dr. Langer also completed a mid-career fellowship at SUNY Buffalo in cerebrovascular disease treatment including aneurysms, AVMs and carotid disease.

Dr. Langer worked at the Continuum Health System at Mount Sinai in New York until 2010, when he joined the neurosurgery department at North Shore-LIJ (now Northwell Health). Dr. Langer established the Moyamoya Center of New York and developed a project focused upon the use of social networking technology and video to enhance the patient experience and improve the medical record. This project has grown into the Health System supported Cirrus Health which continues to creatively disrupt the status quo in patient communication and the current electronic medical record.

In 2013 Dr. Langer was recruited as director of neurosurgery at Lenox Hill Hospital. His goal is to further expand this outstanding clinical entity by creating an entirely new environment for patients and their families. He also maintains an active practice in spinal disease and benign brain tumors including acoustic neuromas and meningiomas.

Dr. Langer has been recognized as a Top Doctor and Best Doctor by numerous publications.He is currently a peer-reviewer for the journals Neurosurgery and AANS Neurosurgeon and is on the medical advisory boards of Box Inc. and Cisco Systems. He is also a founding member of the board of the Brain Technology Institute and an active member of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons, as well as the cerebrovascular subsection of these organizations.

He has appeared on CNN, FOX, ABC and CBS as well as the Dr. Oz Show.He has also frequently quoted in the New York Times and numerous other print news sources. Most recently, Dr. Langer was featured in the Wall Street Journal article "What Patients Need to Remember After Leaving the Hospital" for his innovative technology to record crucial steps of patient's experience in the hospital.

Scientific Publications

Multiportal Combined Transorbital and Transnasal Endoscopic Resection of Fibrous Dysplasia. Tham T, Costantino PD, Bruni M, Langer D, Boockvar J, Singh P [published online Oct 25 2015]. J Neurol Surg Rep. 2015. doi: 10.1055/s-0035-1566126

Forearm Cephalic Vein Graft for Short,"Middle" Flow, Internal Maxillary Artery to Middle Cerebral Artery Bypass. Nossek E., Costantino P.D., Chalif D.J., Ortiz R.O., Dehdashti A.R., Langer D.J., Operative Neurosurgery, Accepted for publication 2015

How I Do It: Combined Direct (STA-MCA) and Indirect (EDAS) EC-IC Bypass. Nossek E, Langer DJ, Acta Neurosurgica, 156(11):2079-2084,2014

Internal Maxillary Artery to Middle Cerebral Artery Bypass: Infratemporal Approach for Subcranial- Intracranial (SC-IC) Bypass. Nossek E., Costantino P, Dehdashti A., Chalif D., Setton A., Eisneberg M., Langer D., Neurosurgery, 2014, Jul;75(1):87-95.

A novel sling technique for microvascular decompression of a rare anomalous vertebral artery causing cervical radiculopathy. Tandon A, Chandela S, Langer D, Sen C. Neurosurg Focus. 2013 Sep;35(3):E2

Bypass for the prevention of ischemic stroke. Rodríguez-Hernández A, Josephson SA, Langer D, Lawton MT.World Neurosurg. 2011 Dec;76(6 Suppl):S72-9. doi: 10.1016/j.wneu.2011.06.032. Review. Erratum in: World Neurosurg. 2012 Dec;78(6):e1

Posterior inferior cerebellar artery to posterior inferior cerebellar artery in situ bypass for the treatment of Bow hunter's-type dynamic ischemia in holovertebral dissection. Kan P, Yashar P, Langer DJ, Siddiqui AH, Levy EI.World Neurosurg. 2012 Nov;78(5):553.e15-7. doi: 10.1016/j.wneu.2011.09.050. Epub 2011 Nov

Cavernous malformation of the oculomotor nerve mimicking a partially thrombosed posterior communicating artery aneurysm: Report of two cases. Wolfe SQ, Manzano G, Langer DJ, Morcos JJ. Neurosurgery. 2011 Apr 14.

Contralateral mini craniotomy for clipping of bilateral ophthalmic artery aneurysms using unilateral proximal carotid control and sugita head frame. Chandela S, Chakraborty S, Ghobrial GM, Jeddis A, Sen C, Langer DJ. World Neurosurg. 2011 Jan;75(1):78-82.

Operative Nuances of Side-to-Side In Situ Posterior Inferior Cerebellar Artery-Posterior Inferior Cerebellar Artery Bypass Procedure. Korja, Miikka; Sen, Chandranath; Langer, David, Neurosurgery 67():ons471-ons477, December 2010

Retrograde trans-posterior communicating artery snare-assisted rescue of lost access to a foreshortened pipeline embolization device: complication management. Hauck EF, Natarajan SK, Langer DJ, Hopkins LN, Siddiqui AH, Levy EI. Neurosurgery. 2010 Dec;67(2 Suppl Operative):495-502

Cerebrovascular surgery: evolution or obsolescence. Levy EI, Siddiqui AH, Hopkins LN, Langer DJ, Ogilvy CS., J Neurosurg. 2009 Jul;111(1):195-7.

Occipital artery-to-posterior inferior cerebellar artery bypass for treatment of bilateral vertebral artery occlusion: the role of quantitative magnetic resonance angiography noninvasive optimal vessel analysis: technical case report. Starke RM, Chwajol M, Lefton D, Sen C, Berenstein A, Langer DJ. Neurosurgery. 2009 Apr;64(4):E779-81

Treatment of giant middle cerebral artery aneurysms with a flow replacement bypass using the excimer laser-assisted nonocclusive anastomosis technique. van Doormaal TP, van der Zwan A, Verweij BH, Han KS, Langer DJ, Tulleken CA. Neurosurgery. 2008 Jul;63(1):12-20

Treatment of giant and large internal carotid artery aneurysms with a high-flow replacement bypass using the excimer laser-assisted nonocclusive anastomosis technique. van Doormaal TP, van der Zwan A, Verweij BH, Langer DJ, Tulleken CA. Neurosurgery. 2008 Jun;62(6 Suppl 3):1411-18

An emerging technology for use in the creation of intracranial-intracranial and extracranial-intracranial cerebral bypass. Langer DJ, Van Der Zwan A, Vajkoczy P, Kivipelto L, Van Doormaal TP, Tulleken CA. Excimer laser-assisted nonocclusive anastomosis. Neurosurg Focus. 2008;24(2):E6

Large Ophthalmic Segment Aneurysms with Anterior Optic Pathway Compression: Assessment of Anatomic and Vision Outcomes after Endosaccular Coiling. Navraj S. Heran, MD, Joon K. Song, MD, Mark J. Kupersmith, MD, Yasunari Niimi, MD, Katsunari Namba, MD, David J. Langer, MD, and Alejandro Berenstein, MD J Neurosurg. 2007 Jun;106(6):968-75.

Treatment of Cerebral Aneurysms with Hydrogel-Coated Platinum Coils (HydroCoil): Early Single-Center Experience. A. Berenstein,, J.K. Song,, Y.Niimi, K. Namba, N.S. Heran, J.L. Brisman, M.C. Nahoum, M. Madrid, D.J. Langer and M.J. Kupersmith, American Journal of Neuroradiology 27:1834-1840, October 2006

Treatment of giant and large internal carotid artery aneurysms with a high-flow replacement bypass using the excimer laser-assisted nonocclusive anastomosis technique. van Doormaal TP, van der Zwan A, Verweij BH, Langer DJ, Tulleken CA. Neurosurgery. 2006 Oct;59(4 Suppl 2)

Monitoring of motor evoked potentials monitoring during cerebral aneurysm surgery: intraoperative changes and postoperative outcome. A. Szelenyi, D. Langer, K. Kothbauer, A. Bueno de Camargo, E. S. Flamm, V. Deletis, J Neurosurgery Vol 105:5, 2006

Diagnosis and Treatment of Occult Subclavian Steal in the Setting of Right Middle Cerebral Ischemia: A Clinical Role for Quantitative MRA? D. J. Langer, D. Lefton, L. Ostengren,, C. Brockington , J. Song , Y. Niimi , P. Bhargava , A. Berenstein, , Neurosurgery 58, No 3: 528-533, March 2006

Embolization of Vein of Galen Malformations: Quantification of Shunt Reduction with MR Non-invasive Optimal Vessel Analysis (NOVA). D. J. Langer, J. K. Song, Y. Niimi, M. Chwajol, D.R. Lefton, J.L. Brisman, M. J. Kupersmith, and A. Berenstein, J. Neurosurgery Pediatrics 104: 41-45, January 2006

ELANA: Excimer Laser Assisted Nonocclusive Anastomosis for Extracranial to Intracranial and Intracranial to Intracranial Bypass: A Review. David J. Langer and PeterVajkoczy, , Skull Base 15, No 3: 191-205, 2005.

Motor Evoked Potential Monitoring During Cerebral Aneurysm Surgery: Technical Aspects and Comparison of Transcranial and Direct Cortical Stimulation. A. Szelenyi, K. Kothbauer, A. Bueno de Camargo, D. Langer, E. Flamm, V. Deletis, Operative Neurosurgery 57, No 4: 331- 338, 2005.

Cavernous Carotid Aneurysms Rarely Cause Subarachnoid Hemorrhage or Major Neurologic Morbidity. M.J. Kupersmith, H. Stiebel-Kalish, R. Huna-Baron, A. Setton, Y. Niimi, D. Langer, A. Berenstein, J. Stroke and Cerebrovascular Diseases, Vol 11, No 1: 9-14, 2002

In Vivo Protein Expression from mRNA Delivered into Adult Rat Brain. K. Kariko, J.M. Keller, V.A. Harris, D.J. Langer, F.S. Welsh, J. Neurosci Methods, 105: 77-86, 2001

Orbital Drainage from Cerebral Arteriovenous Malformations. N.J. Volpe, M.C. Sharma, S.L. Galetta, D.J. Langer, G.T. Liu, R.W. Hurst, E.S. Flamm, Neurosurgery, 46(4): 820-824, 2000.

Hypertension, Small Size, and Deep Venous Drainage Are Associated with Risk of Hemorrhagic Presentation of Cerebral Arteriovenous Malformations, Neurosurgery. D.J. Langer, T.M. Lasner, R.W. Hurst, E.S. Flamm, E.L. Zager, J.T. King, , 42(3): 481-489, 1998

Phosphate-enhanced transfection of cationic lipid-complexed mRNA and plasmid DNA. K.Kariko, A. Kuo, E.S. Barnathan, D.J. Langer, Biochimica et Biophysica Acta, 1369(2): 320-334, 1998

Thermal Preconditioning Before Rat Arterial Balloon Injury: Limitation of Injury and Sustained Reduction of Intimal Thickening. D.G. Neschis, S.D. Safford , P.N. Raghunath, D.J. Langer, M.L. David, A.K. Hanna, J.E. Tomaszewski, K. Kariko, E.S. Barnathan, M.A. Golden, , Arterioscler Thromb Vasc Biol., 18:120-126, 1998

Adenovirus Vector-Mediated Gene Transfer into Human Epileptogenic Brain Slices: Prospects for Gene Therapy in Epilepsy. O'Connor W.M. , Davidson B.L., Kaplitt M.G., Abbey M.V., During M.J., Leone P., Langer D, O'Connor M.J., Freese A. , Experimental Neurology, 148(1):167-178, 1997

Direct Gene Transfer into Human Epileptogenic Hippocampal Tissue with an Adeno-associated Virus Vector: Implications for a gene therapy approach to epilepsy. A. Freese, M. G. Kaplitt, W.M. O'Connor, D.J. Langer, P. Leone, M.J. O'Connor, M.J. During, , Epilepsia, 38(7):759-766, 1997

Regulation of the endothelial cell urokinase type plasminogen activator receptor:evidence for cAMP dependent and protein kinase C dependent pathways. Langer D.J., Kuo A., Kariko K., Ahuja M., Klugherz B., Ivanics K.M., Hoxie J.A., Williams W.V., Liang B.T., Cines D.B., Barnathan E.S., Circulation Research, 72:330-340,1993

Regulation of the Urokinase Receptor on Human Endothelial Cells-Evidence for cAMP Dependent and Independent Pathways. D.J. Langer, A. Kuo, K. Kariko, D.B. Cines, E.S. Barnathan, , Clinical Research 38:319A, 1990

Laser Light Scattering Determination of Size and Particle Composition of Delta Endotoxin Crystals from B. thuringiensis. D.B. Sattelle, D.J. Langer, C.A. Haniff, D.J. Ellar, , Royal Society of Chemistry Dynamic Properties of Biomolecular Assemblies, 1989

Chapters

Chakraborty S., Van Doormaal T, Kivipelto L and Langer D, Extracranial To Intracranial Bypass Using Elana Technique, Cerebral Revascularization: Techniques in Extracranial-to-Intracranial Bypass Surgery, Elsevier Saunders , 2010, p145-153.

Korja M, Kivipelto L, Sen C and Langer D, The State of the Art in Cerebrovascular Bypasses: Side to Side in situ PICA-PICA Bypass, o Intracranial Bypass Using Elana Technique, Cerebral Revascularization: Techniques in Extracranial-to-Intracranial Bypass Surgery, Elsevier Saunders , 2010, p113-118

Schwartz LF and Langer DJ, Clinical Presentation of Cerebral Aneurysms and Subarachnoid Hemorrhage, In: LeRoux PD and Winn HR ed., Management of Cerebral Aneurysms, W.B. Saunders, Philadelphia, 2003

Langer D.J. and Flamm E.S. Surgical Treatment of Anterior Circulation Aneurysms, Neurobase 1999, Stein S. Ed

Langer D.J., Zager E., Flamm E.S., Parasurgical Management of Aneurysmal Subarachnoid Hemorrhage, In: Cruz, J. (ed.), Neurologic and Neurosurgical Emergencies, W.B. Saunders, Philadelphia, p. 205-241

Abstracts

Outcome Analysis for Repeat Cervical Surgery in the Failed Neck Patient, D.J. Langer, R. Weil, P.M. Marcotte, CNS 1997

High Level of Protein Expression Achieved by mRNA Transfection In Cultured Neurons Rat Brain. K. Karikó*, E. S. Barnathan, V. M.-Y. Lee, Y. Rangel, D. J. Langer, F. A. Welsh. , Society for Neuroscience Abstract, 1997

Adenoviral Penton Protein Improves Transfection Efficiency of mRNA and Plasmid DNA in Primary Neuroglial Cells. D.J. Langer, K.J. Fisher, R.W. Malone, J.A. Hecker, E.S. Barnathan, F.A. Welsh, M.A. Dichter, K. Kariko, Society for Neuroscience Abstract, 1996

Gene transfer into Human Hippocampal Tissue Using an Adeno-Associated Virus Vector: Prospects for Gene Therapy in Focal Epilepsy, A. Freese, M.J. O'Connor, D.J. Langer, M. G. Kaplitt, W.M. O'Connor, M.J. During, CNS 1995 Abstract

Feasibility Studies of mRNA Transfection for Intermediate Duration, Perioperative Modulation of CNS Responses Accessible via Cerebrospinal Fluid, J.G, Hecker, D.J. Langer, B.E. Marshall, E.S Barnathan, K. Kariko, AUA 1995 Abstract

Cerebral Arteriovenous Malformations: Risk of Hemorrhage Based on Angiographic and Clinical Criteria, D.J. Langer, T.M. Lasner, R.W. Hurst, J.T. King, E.L. Zager, E.S. Flamm, AANS 1994 Abstract

Charybdotoxin (CTX) Selectively Blocks Calcium Mediated Potassium Conductance that Contributes to the Action Potential Recorded Optically from Nerve Terminals of the Frog Neurohypophysis, A.L. Obaid, D.J. Langer, B.M. Salzberg, Society for Neuroscience Abstract, 1985

Other Publications

Evolution of a Dual-Trained Vascular Neurosurgeon AANS Neurosurgeon Vol 22(2), 2013

Outward Facing Technologies in Health Care, AANS Neurosurgeon, Vol 21(2), 2011

Transportable Imaging- Combining OsiriX for Mac with the iPad for PACS retrieval, AANS Neurosurgeon, Vol 20(2), 2011

Today My Dad Would Be Alive, D.J. Langer, Philadelphia Magazine, March, 1995

Awards

2014 Dignity Healthcare/BOX IT Patient app challenge finalist

1995 AANS/Upjohn Cerebrovascular Resident Research Award

1991 Morris Ginsberg Memorial Prize

1991 I.S. Ravdin Memorial Prize

1991 George Householder Memorial Award

1989 Four Schools Physician Scientist Award Talks

2014 Boxworks 2014 The Innovation Curve in Healthcare: New Technologies and Policy Implications, San Francisco CA

2013 International Perspectives in Neurovascular Disease: Past, Present and Future

2013 Bern European Revascularization Course- In Situ Bypass

2102 CNS Vascular Section: Cerebrovascular Neurosurgery- Are we leading the way or losing our way?

2012 CNS Vascular Section Oral Abstract "Final Results of ELANA IDE Study on High Flow Cerebral Bypasses: Anterior Circulation Aneurysms

2012 AANS/CNS Neurovascular Meeting Bypasss Surgery: The Red- Headed Step Child

2012 AANS/CNS Neurovascular Meeting "Preliminary Results of the ELANA IDE Study on High Flow Cerebral Bypasses- Anterior Circulation Aneurysms

2012 University of Illinois Chicago Grand rounds and Visiting Professor

2012 World Congress on Cerebral Revascularization, St Louis University

2011 University of Cincinnati Grand rounds and Visiting Professor

2011 Allegheny General Hospital Microscopic and Endoscopic Approaches to the Skull Base

2011 University of Bern, Revascularization Course

2011 CNS "ELANA- Indications and Outcomes"

2011 2nd Florida Aneurysm Workshop

2010 MCG Technology Fair Medical records for the iPhone generation

2009 Sidney Hollin Memorial Lecture Mt Sinai School of Medicine

2009 Course Director 2009 Neurosymposium New York City

2009 SUNY Buffalo Neurosurgery Grand Rounds " The Future of Neurovascular Surgery"

2009 3C Conference Jackson Hole "New Technologies in Neurovascular Surgery"

2008 CNS "New Technologies in Neurovascular Surgery"

2008 Young Vascular Neurosurgeons Conference, Sarasota FL

2007 St Louis University World Congress on Cerebral Revascularization

2007 Downstate University Neurosurgical Grand Rounds "Future Technologies In Cerebrovascular Bypass Surgery"

2007 Johns Hopkins University Neurosurgical Grand Rounds "Future Technologies In Cerebrovascular Bypass Surgery"

2007 Columbia University Neurosurgical Grand Rounds "Future Technologies In Cerebrovascular Bypass Surgery"

2007 Allegheny Hospital Neurosurgical Grand Rounds "Future Technologies In Cerebrovascular Bypass Surgery"

2006 St Louis University Cerebral Revascularization Meeting- Course Co-Director

2006 Neurosurgery Grand Rounds University of Texas "New Avenues In High Flow EC-IC Bypass"

2003 Neurosurgery Grand Rounds University of Illinois/Chicago "New Avenues In High Flow EC-IC Bypass"

2002-2005 St Lous University Cerebral Revascularization Faculty "New Avenues In High Flow EC-IC Bypass"

2002-2005Academy of Neurology

The Neurologist™s Role in a Multidisciplinary Approach to Cerebral Aneurysms, Pial and Dural AVMs

2002 AANS/CNS Vascular Section Meeting

Management of Residual Anterior Communicating Artery Aneurysms in Patients with Subarachnoid Hemorrhage

2001 Beth Israel Medical Center CME series Neurosurgical Emergencies

1999 Neurosurgery Grand Rounds Tufts University School of Medicine

Controversies in the Management of Cerebral Arterial Aneurysms

1999 International Society of Neurological Emergencies

Clinical evaluation and management of acute hydrocephalus

Intensive care management of cerebral vasospasm1997 CNS Annual Meeting

Outcome Analysis for Repeat Cervical Surgery in the 'Failed Neck' Patient

1996 Sedona Spring Brain Conference Plenary speaker

Bypassing the Nucleus, mRNA as Gene Therapy

1996 Neuroemergency Meeting

Intensive Care Management of Cerebral Arterial Vasospasm

Management of Acute Hydrocephalus, A Contemporary Approach

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